Link to publications on Research Gate or on PubMed.
My main research topics are:
- Influence of Environmental factors, including the exposome, on human health
- Methodological issues in environmental and reproductive epidemiology
- Management of environmental risks
- Temporal changes in human fecundity
1. Environment and human health
Morelli X, Gabet S, Rieux C, Bouscasse H, Mathy S, Slama R (2019) Which decreases in air pollution should be targeted to bring health and economic beneets and improve environmental justice? Environment International 129: 538-550. Link
Agier L, … Slama R, Vrijheid M*; Siroux V*, Early life exposome and lung function in children from the HELIX cohort, Lancet Planetary Health, 2019. Link
Tamayo-Uria, I., et al., The early-life exposome: Description and patterns in six European countries. Environ Int, 2019. 123: p. 189-200. Link
Philippat, C., et al., Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France). Environ Health Perspect, 2019. 127(1): p. 17002. Link
Warembourg C, Basagaña X, Seminati C, de Bont J, Granum B, Lyon-Caen S, Manzano-Salgado CB, Pin I, Sakhi AK, Siroux V, Slama R, Urquiza J, Vrijheid M, Thomsen C, Casas M. Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy. Int J Hyg Environ Health. 2018
Maitre L, de Bont J, Casas M, …Nieuwenhuijsen MJ, Slama R, Thomsen C, Wright J, Vrijheid M, Human Early Life Exposome (HELIX) study: a European population-based exposome cohort. BMJOpen, 2018, 8(9):e021311. doi: 10.1136/bmjopen-2017-021311
Haug LS, Sakhi AK, Cequier E, Casas M, …, Slama R, Sunyer J, Urquiza J, Vafeiadi M, Wright J, Vrijheid M, Thomsen C. In-utero and childhood chemical exposome in six European mother-child cohorts. Env Int, 2018, 121(Pt 1):751-763. doi: 10.1016/j.envint.2018.09.056.
Nakiwala D, Peyre H, Heude B, Bernard JY, Béranger R, Slama R, Philippat C, In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years, Env Health, Environ Health. 2018 Feb 20;17(1):17.
Warembourg C, Botton J, Lelong N, Rouget F, Khoshnood B, Le Gléau F, Monfort C, Labat L, Pierre F, Heude B, Slama R, Multigner L, Charles MA, Cordier S, Garlantézec R., Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case-control study, Occup Environ Med. 2018;75(1):59-65
Vernet C, … Siroux V*, Slama R*, In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five Year-old Boys: a Prospective study, Env Health Perspect, 2017, 8;125(9):097006.
Ouidir M… Slama R, Is atmospheric pollution exposure during pregnancy associated with individual and contextual characteristics? A nationwide study in France, J Epid Commun Health, 2017;71(10):1026-1036.
Benmerad M, Slama R, Botturi K, Claustre J, Roux A, Sage E, Reynaud-Gaubert M, Gomez C, Kessler R, Brugière O, Mornex JF, Mussot S, Dahan M, Boussaud V, Danner-Boucher I, Dromer C, Knoop C, Auffray A, Lepeule J, Malherbe L, Meleux F, Nicod L, Magnan A, Pison C, Siroux V; SysCLAD consortium, Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study, 49, Eur Respir J. 2017
Giorgis-Allemand L, … Slama R, Influence of Environmental Pollutants on the Risk of Preterm Birth: Paths forwards [Invited commentary], 185:247-258, Am J Epidemiol, 2017
Giorgis-Allemand L, … Slama R, The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth [accompanied by an invited commentary], 185:262-263, Am J Epidemiol, 2017
Westergaard N, Gehring U, Slama R, Pedersen M, Ambient air pollution and low birth weight – are some women more vulnerable than others? 104:146-154, Environ Int. 2017
Valentino SA, Tarrade A, Aioun J, Mourier E, Richard C, Dahirel M, … Slama R, Chavatte-Palmer P. 2016. Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits. 13:39, Part Fibre Toxicol, 2016.
Botton J, Philippat C, Calafat AM, Carles S, Charles MA, Slama R, The Eden Mother-Child Cohort Study Group. Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age. 151:601-609. Environ Res. 2016
Heude B, Forhan A, Slama R, Douhaud L, Bedel S, Saurel-Cubizolles MJ, Hankard R, Thiebaugeorges O, De Agostini M, Annesi-Maesano I, Kaminski M, Charles MA; EDEN mother-child cohort study group., Cohort Profile: The EDEN mother-child cohort on the prenatal and early postnatal determinants of child health and development, 45:353-63, Int J Epidemiol. 2016
Gruzieva O, … Slama R, Sunyer J, Söderhäll C, Yao J, London SJ, Pershagen G, Koppelman GH, Melén E, Epigenome-wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure, Env Health Perspect, 2016
Siroux V, Agier L, Slama R, The exposome concept: a challenge and a potential driver for environmental health research, European Respiratory Review (in press) DOI: 10.1183/16000617.0034-2016
Morelli X, Rieux C, Cyrys J, Forsberg B, Slama R: Air pollution, health and social deprivation: A fine-scale risk assessment. Environ Res 2016, 147:59-70.
Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM, Basagaña X, Bernard C, Cirach M, Forastiere F, de Hoogh K, Gražulevičienė R, Gruzieva O, Hoek G, Jedynska A, Klümper C, Kooter IM, Krämer U, Kukkonen J, Porta D, Postma DS, Raaschou-Nielsen O, van Rossem L, Sunyer J, Sørensen M, Tsai MY, Vrijkotte TG, Wilhelm M, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, Slama R, Elemental Constituents of Particulate Matter and Newborn’s Size in Eight European Cohorts. Environ Health Perspect; 124:141-150, 2016
Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, Almqvist C, Aranbarri A, Beelen R, Badaloni C, Cesaroni G, de Nazelle A, Estarlich M, Forastiere F, Forns J, Gehring U, Ibarluzea J, Jaddoe VW, Korek M, Lichtenstein P, Nieuwenhuijsen MJ, Rebagliato M, Slama R, Tiemeier H, Verhulst FC, Volk HE, Pershagen G, Brunekreef B, Sunyer J, Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project, Env Health Perspect, 124:133-140, 2016
Slama R, Vrijheid M, Some Challenges of Studies Aiming to Relate the Exposome to Human Health, (Invited Editorial), 72:383-4, Occup Env Med 2015
Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražulevičienė R, Gutzkow KB, Julvez J, Keun HC, Kogevinas M, McEachan RR, Meltzer HM, Sabidó E, Schwarze PE, Siroux V, Sunyer J, Want EJ, Zeman F, Nieuwenhuijsen MJ, The human early-life exposome (HELIX): project rationale and design, Environ Health Perspect. 122(6):535-44, 2014.
Pedersen M, Stayner L, Slama R, Sørensen M, Figueras F, Nieuwenhuijsen MJ, Raaschou-Nielsen O, Dadvand P, Ambient air pollution and pregnancy-induced hypertensive disorders: a systematic review and meta-analysis, Hypertension, 64:494-500, 2014.
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Klümper C, Kogevinas M, Krämer U, Larroque B, Lertxundi A, Lertxuni N, Murcia M, Navel V, Nieuwenhuijsen M, Porta D, Ramos R, Roumeliotaki T, Slama R, Sørensen M, Stephanou EG, Sugiri D, Tardón A, Tiemeier H, Tiesler CM, Verhulst FC, Vrijkotte T, Wilhelm M, Brunekreef B, Pershagen G, Sunyer J, Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts, Epidemiology, 25(5):636-47, 2014.
Philippat C, Botton J, Calafat A, Ye X, Charles MA and Slama R, Longitudinal Associations between Prenatal Exposures to Phenols and Pre- and Post-natal Growth in Boys. Epidemiology, 25:625-635, 2014
Sellier Y, … Slama R, Lepeule J, Health effects of ambient air pollution: Do different methods for estimating exposure lead to different results, Env Int, 66:165-73, 2014.
Vrijheid M, Slama R, … Nieuwenhuijsen MJ. The Human Early-Life Exposome (HELIX): Project Rationale and Design. Environ Health Perspect 122:535-544, 2014.
Pedersen M, Giorgis-Allemand L, Bernard C, Aguilera I, Nybo Andersen AM, Ballester F, Beelen
2. Methodological issues in environmental and reproductive epidemiology
Eijkemans MJC, Leridon H, Keiding N, Slama R. A Systematic Comparison of Designs to Study Human Fecundity. Epidemiology, 2019.
Casas M… Slama R*, Vrijheid M*, Variability of Urinary Concentrations of Non-Persistent Chemicals in Pregnant Women and School-aged Children, Env Int, 121: 561-573, 2018. *Co last-authorship. Link
Basagana X, Pedersen M, Barrera-Gomez J, Gehring U, Giorgis-Allemand L, Hoek G, Stafoggia M, Nieuwenhuijsen MJ, Brunekreef B, Slama R. Analysis of multicentre epidemiological studies: contrasting fixed or random effects modelling and meta-analysis. Int J Epidemiol 47:1343-1354, 2018.
Vernet C, Philippat C, Calafat AM, Ye X, Lyon-Caen S, Siroux V, Schisterman E, Slama R, Within-day, between-day and between-week variability of urinary concentrations of phenol biomarkers in pregnant women, Env Health Perspect, (in press)
Barrera-Gómez J, Agier L, Portengen L, Chadeau-Hyam M, Giorgis-Allemand L, Siroux V, Robinson O, Vlaanderen J, González JR, Nieuwenhuijsen M, Vineis P, Vrijheid M, Vermeulen R, Slama R, Basagaña X, A systematic comparison of statistical methods to detect interactions in exposome-health associations, Environmental Health, 2017;16(1):74.
Tonne C, Basagaña X, Chaix B, Huynen M, Hystad P, Nawrot TS, Slama R, Vermeulen R, Weuve J, Nieuwenhuijsen M. New frontiers for environmental epidemiology in a changing world. 104:155-162, Environ Int. 2017
Smarr MM, Sapra KJ, Gemmill A, Kahn LG, Wise LA, Lynch CD, Factor-Litvak P, Mumford SL, Skakkebaek NE, Slama R, Lobdell DT, Stanford JB, Jensen TK, Boyle EH, Eisenberg ML, Turek PJ, Sundaram R, Thoma ME, Buck Louis GM. Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer. 32:499-504, Hum Reprod. 2017
Maitre L, Lau CE, Vizcaino E, Robinson O, Casas M, Siskos AP, Want EJ, Athersuch T, Slama R, Vrijheid M, Keun HC, Coen M. Assessment of metabolic phenotypic variability in children’s urine using 1H NMR spectroscopy. 19;7:46082. Sci Rep. 2017
Agier L, Portengen L, Chadeau-Hyam M, Basagaña X, Giorgis-Allemand L, Siroux V, … Slama R*, Vermeulen R* (*joint last authorship). A systematic comparison of linear regression-based statistical methods to assess exposome-health associations. Env Health Perspect. 124(12): 1848-1856. 2016. Link.
Perrier F, Giorgis Allemand L, Slama R, Philippat C. Within-subject pooling of biological samples as a way to reduce exposure misclassification in biomarker-based studies of chemicals with high temporal variability. Epidemiology 27: 378-388. 2016.
de Hoogh K, Gulliver J, Donkelaar AV, Martin RV, Marshall JD, Bechle MJ, Cesaroni G, Pradas MC, Dedele A, Eeftens M, Forsberg B, Galassi C, Heinrich J, Hoffmann B, Jacquemin B, Katsouyanni K, Korek M, Künzli N, Lindley SJ, Lepeule J, Meleux F, de Nazelle A, Nieuwenhuijsen M, Nystad W, Raaschou-Nielsen O, Peters A, Peuch VH, Rouil L, Udvardy O, Slama R, Stempfelet M, Stephanou EG, Tsai MY, Yli-Tuomi T, Weinmayr G, Brunekreef B, Vienneau D, Hoek G. Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data. 151:1-10, Environ Res. 2016
Carles S, Charles MA, Forhan A, Slama R, Heude B, Botton J; EDEN mother child study group. A Novel Method to Describe Early Offspring Body Mass Index (BMI) Trajectories and to Study Its Determinants, 11(6):e0157766, PLoS One. 2016.
Gasbarra D, Arjas E, Vehtari A, Slama R, Keiding N, The current duration design for estimating the time to pregnancy distribution: a nonparametric Bayesian perspective, Lifetime Data Analysis, (EPub) June 12 2015.
Keiding N, Slama R, Time to pregnancy in the real world (Invited commentary), Epidemiology, 26: 119-121. 2015.
Aguilera I, Foraster M, Basagaña X, Corradi E, Deltell A, Morelli X, Phuleria HC, Ragettli MS, Rivera M, Thomasson A, Slama R, Künzli N. Application of land use regression modelling to assess the spatial distribution of road traffic noise in three European cities. J Expo Sci Environ Epidemiol. 25:97-105, 2015.
Morelli X, …, Slama R. Short-term associations between traffic-related noise, particle number and traffic flow in three European cities, Atm Env, 103:25-33. 2015
Robinson O, Basagaña X, Agier L, de Castro M, Hernandez-Ferrer C, Gonzalez JR, Grimalt JO, Nieuwenhuijsen M, Sunyer J, Slama R, Vrijheid M, The Pregnancy Exposome: Multiple Environmental Exposures in the INMA-Sabadell Birth Cohort, 49:10632-41, Environ Sci Technol. 2015
Slama R, Ballester F, Casas M, Cordier S, Eggesbo M, Iniguez C, Nieuwenhuijsen M, Philippat C, Rey S, Vandentorren S, Vrijheid M. Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes. Epidemiol Rev, 148-64, 2014.
3. Management of environmental risks
Slama R, Le rôle des chercheurs dans l’alerte en santé environnementale. Revue de l’ADSP, 106. 2019.
Solecki R, Kortenkamp A, Bergman Å, Chahoud I, Degen GH, Dietrich D, Greim H, Håkansson H, Hass U, Husoy T, Jacobs M, Jobling S, Mantovani A, Marx-Stoelting P, Piersma A, Ritz V, Slama R, Stahlmann R, van den Berg M, Zoeller RT, Boobis AR. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.91:1001-1006, Arch Toxicol. 2017
Trasande L, Vandenberg LN, Bourguignon JP, Myers JP, Slama R, Vom Saal F, Zoeller RT. Peer-reviewed and unbiased research, rather than ‘sound science’, should be used to evaluate endocrine-disrupting chemicals.70:1051-1056, J Epidemiol Community Health. 2016
Kortenkamp A, Bourguignon JP, Slama R, Bergman Å, Demeneix B, Ivell R, Panzica G, Trasande L, Zoeller RT. EU regulation of endocrine disruptors: a missed opportunity.4:649-50, Lancet Diabetes Endocrinol. 2016
Bourguignon JP, Slama R, Bergman Å, Demeneix B, Ivell R, Kortenkamp A, Panzica G, Trasande L, Zoeller RT. Science-based regulation of endocrine disrupting chemicals in Europe: which approach?4:643-6, Lancet Diabetes Endocrinol. 2016
Bourguignon JP, Slama R, et al., Identifying Chemicals That Disrupt Hormone Systems And Threaten Health: The Right Approach Keeps Refinement Possible, The Lancet Diabetes and Endocrinology. 2016
Slama R, Bourguignon JP, Demeneix B, et al. Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine Disrupting Substances in the European Union [Commentary]. 124:1497-1503, Environmental Health Perspectives, 2016. Link.
4. Temporal changes in human fecundity
Slama R and Siroux V, On influencing population means, Epidemiology, 23: 501-3, 2012.
Leridon H and Slama R, The impact of a decline in fecundity and of birth postponement on final number of children and demand for ART, Human Reprod, 23: 1312-19, 2008.
Slama R, Jensen TK, Scheike T, Ducot B, Spira A, Keiding N, How Would a Decline in Sperm Concentration Over Time Influence the Probability of Pregnancy? Epidemiology, 15: 458-65, 2004.
Slama R and Leridon H, How much of the decline in sperm counts could be explained by the hypothesis of relaxed reproductive selection? Epidemiology,13: 613-615, 2002.
Slama R, Eustache F, Ducot B, Jensen TK, Jørgensen N, Horte A, Irvine S, Suominen J, Andersen AG, Auger J, Vierula M, Toppari J, Andersen AN, Keiding N, Skakkebaek NE, Spira A, Jouannet P, Time to pregnancy and semen parameters: a cross sectional study among fertile couples from four European cities. Human Reprod, 17: 503-515, 2002.
Jensen TK, Keiding N, Scheike T, Slama R, Spira A, Declining Human Fertility? Fertility and Sterility, 73: 421-3, 2000.
Rémy Slama 